Re-watch this meeting below:

Tuesday 25 August, 14:00 – 15:00 BST

Organised by Pete Aldiss, University of Edinburgh, UK and Jo Lewis, University of Cambridge, UK

The central nervous system plays a major role in maintaining a balance between the energy required for survival and the energy provided by feeding. The regulation is complex, with genetic, hormonal, behavioural and societal influences. The aetiology of obesity is therefore multifactorial. Recent evidence suggests that bile acids act as metabolic integrators – an idea explored by Ashley Castellanos-Jankiewicz (INSERM Bordeaux Neurocampus, France).

Amy Worth (University of Manchester, UK) demonstrated the GDF15 receptor, GFRAL, is located in a subset of cholecystokinin neurons, which span the area postrema and the nucleus tractus solitarius of the mouse. These populations are responsible for the conditioned taste and place aversions, in addition to the anorexia, GDF15 causes.

This is part of the ‘Physiology of Obesity: From Mechanisms to Medicine’ series.

Hear from Early Career Researchers as they explore the molecular, cellular, and neural mechanisms, as well as behavioural aspects, underlying obesity.