British statesman Charles James Fox managed to have two aunts who died 171 years apart:
Fox’s grandfather married twice — once at 27 and once at 76. A baby produced by the first marriage died in 1655, and a son produced by the second marriage married a woman whose sister died in 1826.
Fox himself died in 1806, but his widow survived until 1842 — nearly 200 years after the death of her aunt-by-marriage.